PhD / Post-Doc Position
Cryo-Electron Microscopy and Tomography
The cryo-electron microscopy group of the Buchmann Institute for Molecular Life Sciences is seeking an enthusiastic, highly motivated individual with a degree in biology or biochemistry to occupy a PhD or a Post-Doc position.
The PhD / Post-Doc position is funded by the DFG (Deutsche Forschungsgemeinschaft). The aim of the project is to analyze the cell-cell junctions of the fruit fly Drosophila melanogasterby electron tomography and fluorescence light microscopy techniques. The project addresses the basic question of the formation of the cell-cell junctions during the dorsal closure during late embryogenesis. Cell-cell junctions play a major role in adhesion, morphogenesis and cellular proliferation. The molecular architecture of the junctions is not yet known however its knowledge is essential to explain events with direct implication in development and disease. Electron tomography achieves a resolution sufficient to visualize individual molecules. The scientific focus of the work will be on the actin and microtubule interactions with the cell-cell junctions and accurately visualize the process with molecular resolution. The DC has been extensively studied and various mutants are available for comparative studies.
The group is interdisciplinary composed of biologists, physicists, and biochemists. The laboratory is excellently equipped with electron and light microscopes. Excellent knowledge in biology and biochemistry is an essential requirement for applicants. The successful applicant does not require any technical knowledge in electron tomography, however, he/she should be interested in learning the technique in order to be able to quantitatively analyze the data.